Christina Applegate has never been one to stay silent—on screen or in life. From her early days as the iconic Kelly Bundy to her raw performances in Dead to Me, she’s brought depth, humor, and grit to every role. But now, her most powerful story isn’t scripted—it’s real. And it’s unfolding in real-time.

Since revealing her multiple sclerosis (MS) diagnosis in 2021, Applegate has offered fans a rare kind of honesty. And in a recent heartfelt post, she shared a glimpse into her personal dreams—those she still hopes to realize in the time she has left.

A Tweet That Stopped the Internet

“I want to work with Shirley MacLaine. And do shots with Cher! And yes my days are so big. Just saying.”

That’s how Applegate summed up her hopes in a single, emotionally loaded tweet. It wasn’t just a bucket list—it was a love letter to life, to resilience, and to a little bit of joy in the face of a brutal disease.

She added, “I wish I could work with Shirley. That’s all. Woke up and that dream I have had for my whole life, washed over me. And I wept for a minute. And I’m sure I will again.”

Let that sink in. One of the most beloved actresses of her generation, still dreaming, still fighting, still making plans—even while acknowledging the weight of her condition.

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Living with MS: A Battle Behind the Curtain

Applegate first shared her diagnosis with the world in August 2021. In her own words: “Hi friends. A few months ago I was diagnosed with MS. It’s been a strange journey. But I have been so supported by people that I know who also have this condition.”

MS, a chronic and unpredictable disease of the central nervous system, affects every patient differently. Some lose mobility quickly. Others face years of slow decline. There is no cure.

But Christina has handled her diagnosis with fierce honesty. “We wake up and take the indicated action,” she wrote—borrowing words from a friend with MS. “And that’s what I do.”

Her words resonate not just with fans, but with countless others living with invisible illnesses—those who wake up daily not knowing how their bodies will behave, but choosing to keep going anyway.

The Power of Humor and Hope

If there’s one thing that hasn’t changed in Applegate’s journey, it’s her signature wit. Even in the face of physical decline, she keeps her sense of humor alive. It’s not just coping—it’s survival.

Wanting to share shots with Cher? That’s not just a fantasy. It’s a nod to the boldness she refuses to give up. It’s laughter in the dark. And honestly, it’s peak Christina—unfiltered, unflinching, unforgettable.

She makes space for tears, sure. But she also makes space for fun, for dreams, and for whatever adventures might still be ahead.

Her Legacy: More Than Acting

While fans will always remember her for roles in Married… with Children, Anchorman, and Dead to Me, Christina Applegate’s true legacy may not lie in what she’s done on-screen—but what she’s doing right now.

She’s becoming a beacon for people dealing with chronic illness. She’s showing that vulnerability is strength. That it’s okay to not be okay—and still want to chase joy. That it’s human to grieve and still laugh in the same breath.

She doesn’t sugarcoat the reality. She faces it head-on, and that’s exactly what makes her so magnetic right now.

Why Shirley MacLaine? Why Cher?

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Applegate’s dream collaborators aren’t random picks. They’re legends—women who’ve defied time, broken rules, and lived unapologetically.

Shirley MacLaine, an Oscar-winning actress and spiritual thinker, represents the kind of depth Applegate admires. A force of nature, with a career that spans over 70 years. Working with her would be like passing the torch—and receiving one.

And Cher? Come on. Cher is energy. She’s attitude. She’s pure fire. Wanting to do shots with Cher isn’t just about the alcohol—it’s about spirit, freedom, and defiance. It’s about refusing to let a disease dictate how you live your last great days.

Making Peace with the Uncertain

It’s hard not to feel emotional reading Applegate’s reflections. Because when she talks about “the days I have left,” it’s not a metaphor. It’s reality. She’s not pretending MS doesn’t change everything—it does.

But she’s not letting it define the end of her story, either.

There’s something haunting and beautiful in that balance. She’s not fighting MS with toxic positivity or false hope. She’s fighting it with presence—with bold, honest, real life.

Conclusion: The Days Ahead Matter Most

Christina Applegate’s journey with MS isn’t over. And she’s not finished dreaming, laughing, or fighting for every ounce of joy this life has to offer.

From wanting to act with Shirley MacLaine to clinking shot glasses with Cher, her goals may be simple—but they’re deeply human. They remind us that we don’t have to climb mountains to live meaningfully. Sometimes, it’s just about one more moment. One more laugh. One more dream chased.